Northern Illinois vs Arizona Prediction, Pick, College Football Odds for Saturday, Sept. 19

The Northern Illinois Huskies take on the Arizona Wildcats in Tucson, AZ. Kickoff is set for 10:30 p.m. ET on TNT and HBO Max.

Arizona is favored by -33.5 points on the spread. Northern Illinois, meanwhile, enters as a +33.5 underdog and is +5500 on the moneyline to pull off the upset. The over/under sits at 49.5 total points.

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Here’s my Northern Illinois vs. Arizona prediction and college football pick for Saturday, September 19, 2026.

Northern Illinois vs. Arizona Pick: Arizona -33.5

My Arizona vs. Northern Illinois best bet is on the Wildcats to cover the spread. Find the best line available on our live NCAAF odds page.

Northern Illinois vs Arizona Odds

Northern Illinois vs Arizona point spread: Arizona -33.5 (-110), Northern Illinois +33.5 (-110)

Northern Illinois vs Arizona over/under: 49.5 (-115o / -105u)

Northern Illinois vs Arizona moneyline: Northern Illinois +5500

Northern Illinois enters Tucson still searching for its first victory. The Huskies opened the season with a 40-0 loss at Iowa before falling, 28-24, to Illinois State last week.

Sitting at 0-2, NIU now goes back up to Power 4 competition, playing an irritated opponent in front of its home crowd.

The biggest problem has been the offense.

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The Huskies ranked near the bottom of FBS in most offensive categories in 2025, and those struggles have carried over into 2026.

Through two games, Northern Illinois ranks 131st nationally in Success Rate, 131st in Passing Success Rate and 138th in Points Per Opportunity.

It’s been flat-out difficult for the Huskies to sustain drives and convert scoring opportunities when they do get on the move.

To the their credit, the defense has been more competitive. Northern Illinois ranks 43rd nationally in Points Per Opportunity allowed and has done a respectable job limiting explosive plays in certain situations.

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The problem is that the defense has spent far too much time on the field because the offense has failed to sustain drives. That’s rarely a recipe…

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Publish date : 2026-09-19 10:20:00

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