Missouri vs Kansas Prediction, Picks & Early Odds: College Football Week 2

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The Border War returns with Missouri favored on the road, but the number may be giving Kansas too little respect. My Missouri vs. Kansas predictions break down the spread and total for Friday night’s rematch from last season. 

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Check out the rest of our college football picks for Week 2.

Missouri vs Kansas predictions

For help understanding Kalshi probabilities, see our odds calculator.

Percentages courtesy of Kalshi, one of the best prediction market apps.

Early Missouri vs Kansas spread pick: Kansas +5.5

Kalshi probability: 52%

This is the second of a two-game year-over-year series between these schools. As -5.5 home favorites, Missouri beat Kansas 42-31 last season. Mizzou laying as many points in Kansas feels wrong. These teams are about the same as when they met around this time last year.

In fact, the Tigers had 15 returning starters last season compared to 12 this year. The Jayhawks had 10 returning in 2025 and 12 this season. Both teams have different starting quarterbacks this year and lost three of their four top wide receivers.

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Missouri failed to cover as -56.5 favorites in a 54-14 win over Arkansas-Pine Bluff last week, whereas Kansas beat the spread as -44.5 favorites in its 51-6 victory over Long Island University. Neither win is impressive since both were FCS programs, but at least the Jayhawks covered the spread in their first game.

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Early Missouri vs Kansas total pick: Under 50.5 

Kalshi probability: 54%

Since both teams flipped 50 Burgers in their season openers, the total is only 50.5, and…

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Publish date : 2026-09-08 20:37:00

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