March Madness Moneyline Picks for Saturday, April 4

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It’s been 38 years since one conference put two teams in the national title game.

If the odds are right, the Big Ten Conference could finally do it, with the Illinois Fighting Illini taking on the UConn Huskies and the Michigan Wolverines facing the Arizona Wildcats in Saturday’s Final Four.

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I’ve got both my moneyline predictions going the Big Ten’s way, setting up an Illinois vs. Michigan title game on Monday night.

Read on for my March Madness picks for Saturday, April 4.

March Madness moneyline picks on Saturday, April 4

Matchup

Pick

Illinois
vs
UConn

-135

Arizona
vs
Michigan

-120

Lines courtesy of bet365.

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Expert March Madness Final Four moneyline picks for Saturday

No. 3 Illinois vs No. 2 UConn: Illinois (-135)

The Illinois Fighting Illini own the No. 1 offense in the country at 131.8 adjusted efficiency, the third-best offensive rebounding rate, and a turnover rate inside the Top 10 —all while ranking 22nd in 2-point field goal percentage.

The UConn Huskies’ defense is elite, but Illinois has the size advantage across the board and the offensive firepower to overwhelm them, with second-chance points off the glass being the difference.

The Huskies’ experience matters, but this Illinois offense doesn’t care and will be playing for the National Championship.

Popular March Madness markets

No. 1 Michigan vs No. 1 Arizona: Michigan (-120)

The Michigan Wolverines boast an experience advantage, and…

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Publish date : 2026-04-03 15:06:00

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