March Madness Moneyline Picks for Friday, March 27

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The remaining Elite Eight spots will be decided Friday night when eight outstanding teams meet in the Sweet 16.

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We’ll see what promises to be four exceptional matchups, and I’ve found two underdogs with a good chance to play spoiler, including Alabama knocking off Michigan. 

Read on for my March Madness picks for Friday, March 27. 

March Madness moneyline picks on Friday, March 27

Matchup

Pick

St. John’s
vs
Duke

-280

Alabama
vs
Michigan

+375

Michigan State
vs
UConn

+110

Tennessee
vs
Iowa State

-180

Lines courtesy of bet365.

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Expert March Madness Sweet 16 moneyline picks for Friday

No. 5 St. John’s vs No. 1 Duke:  Duke (-280)

The Duke Blue Devils enter on a 13-game winning streak, backed by KenPom’s top-ranked defense, while the St. John’s Red Storm relies on physicality to stay competitive.

The Red Storm can slow the pace and make Duke uncomfortable, but they lack the offensive firepower to create damaging separation. St. John’s can hang around, but Duke’s depth and shot-making should take over late and carry them to the Elite Eight.

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No. 4 Alabama vs No. 1 Michigan:  Alabama (+375)

The Michigan Wolverines bring a more efficient offense into this matchup, but this game sets up for pace and points, which favors the Alabama Crimson Tide.

Both teams are comfortable playing fast and loose, and that’s where Michigan could feel the loss of L.J. Cason’s perimeter defense and spark off…

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Publish date : 2026-03-27 10:00:00

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