USA TODAY Sports Network picks for Iowa State vs Tennessee in Sweet 16

March 25, 2026 College Basketball

Iowa State basketball travels to Chicago this week to play Tennessee in the Sweet 16 of March Madness.

The Cyclones and Volunteers will meet at 9:10 p.m. CT on Friday at United Center. TBS has the telecast.

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Iowa State was a 4.5-point favorite as of Tuesday evening. Here are game predictions from USA TODAY Sports Network staffers:

More: Iowa State basketball vs Tennessee live updates, news, bracket predictions, odds

USA TODAY Sports predictions for Iowa State vs. Tennessee

Blake Toppmeyer: Tennessee

Paul Myerberg: Iowa State

Jordan Mendoza: Iowa State

Austin Curtright: Iowa State

You can find all of their Sweet 16 predictions here.

This article originally appeared on Des Moines Register: USA TODAY Sports Network picks for Iowa State vs Tennessee in Sweet 16


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Publish date : 2026-03-25 10:30:00

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