NCAA Tournament and March Madness Round of 32 Best Bets, Picks, Odds: Michigan, Texas, Vanderbilt, MSU, More!

After a successful and chalky round of 64 in the NCAA Tournament, let’s turn our attention to the Saturday slate for the round of 32 and potential underdogs to pull the upset. All odds are courtesy of DraftKings.

Saint Louis vs Michigan (-12.5): O/U 161.5

Saturday starts off with an anticipated track meet between Michigan and Saint Louis. Michigan scored 50 first-half points versus Howard and 101 for the game, while Saint Louis put up 49 first-half points against Georgia and 102 for the game!

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The Billikens play at the 19th-quickest tempo in the country and fourth-fastest on offense, while the Wolverines are 22nd-quickest overall and 13th on offense. Per Kenpom, Michigan owns the seventh-best offense in the nation and Saint Louis the 43rd, so everything is trending toward tons of points.

Saint Louis shoots 40.2% from three (2nd-best) and had a bit of a down game with 9-of-28 (32.1%) against Georgia. However, the Billikens recorded 27 assists and 47 rebounds in that game, purely putting on a show. No matter what the score is, Saint Louis will shoot the triple and the way to beat Michigan is to outshoot them and use the pick-and-roll, which Saint Louis is efficient in both.

One of the struggle areas for Saint Louis is allowing opponents to get the free-throw line. The Billikens allow 23.3% of opponents points to come from the free-throw line (32nd-most) and the Bulldogs had 26 attempts in the round of 64. Michigan shot 77.1% from the line in Big Ten play and scored 20% of their points from the charity stripe, so I do see free points for the Wolverines. Both squads have elite two-point and three-point defense, but I don’t think it will look like it today, especially with the anticipated tempo. I like the Over 161.5.

Pick: Over 161.5 (1 unit)

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Louisville vs Michigan State (-4.5): O/U 151.5

Both Louisville and Michigan State enter as top 25 teams offensively and defensively per Kenpom, plus are top 100 in rebounding and three-point shooting. This should be one…

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Publish date : 2026-03-21 13:41:00

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