March Madness Picks Against the Spread for Sunday, March 22

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I pick the winners against the spread with my March Madness picks for every Round of 32 game on Sunday, March 22.

March Madness against the spread picks on Sunday, March 22

Matchup

Pick

Miami 
vs
Purdue

+7.5

Kentucky
vs
Iowa State

-5

St. John’s
vs
Kansas

-3.5

Tennessee
vs
Virginia

-1

Iowa
vs
Florida

+10.5

Utah State
vs
Arizona

-12.5

UCLA
vs
UConn

+4

Texas Tech
vs
Alabama

-1

Lines courtesy of bet365.

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Expert March Madness Round 2 ATS picks for Sunday

No. 7 Miami vs No. 2 Purdue:  Miami +7.5

For all the talk about the Purdue Boilermakers’ offense, it’s easy to lose track of how lackluster the defense has been for much of the year.

Matt Painter’s squad is just 115th in adjusted defensive efficiency over the last month (BartTorvik), making it difficult to find margin against tougher competition. 

The Miami Hurricanes are an undervalued commodity (8-3 ATS in their last 11), and they’ll find success at the rim against Purdue’s 277th-ranked 2-point defense (53.3%).

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No. 7 Kentucky vs No. 2 Iowa State:  Iowa State -5

Joshua Jefferson’s ankle injury is a major concern, but the Iowa State Cyclones have the depth to compensate. That was evident when they set the program record for the largest margin of victory in an NCAA Tournament game, despite losing their top player…

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Publish date : 2026-03-21 18:58:00

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