March Madness Moneyline Picks for Saturday, March 21

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The 2026 edition of March Madness continues on Saturday with eight games on the NCAA Tournament schedule.

We’ve already seen our share of upsets, and my second-round college basketball predictions are looking at three potential Round of 32 underdog wins.

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Read on for my March Madness picks for Saturday, March 21.

March Madness moneyline picks on Saturday, March 21

Matchup

Pick

Saint Louis
vs
 Michigan

-900

 Louisville
vs
 Michigan State

-170

TCU
vs
 Duke

+400

Texas A&M
vs
 Houston

-550

Texas
vs
 Gonzaga

-225

VCU
vs
 Illinois

-600

 Vanderbilt
vs
 Nebraska

+120

High Point
vs
Arkansas

+500

Lines courtesy of bet365.

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Expert March Madness Round 2 moneyline picks for Saturday

No. 9 Saint Louis vs No. 1 Michigan: Michigan (-900)

The Michigan Wolverines’ elite defense faces a lethal test against the Saint Louis Billikens’ second-ranked effective field goal percentage. But while the Billikens’ perimeter spacing and Robbie Avila’s playmaking present “giant-killer” potential, Michigan’s Top-10 efficiency on both ends and massive interior size advantage should secure the victory.

No. 6 Louisville vs No. 3 Michigan State: Michigan State (-170)

The Michigan State Spartans’ top-ranked defensive rebounding faces the Louisville Cardinals’ high-volume perimeter attack. With Cardinals star Mikel Brown Jr. potentially sidelined, the Spartans’ interior strength and Jeremy Fears Jr.’s…

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Publish date : 2026-03-20 17:08:00

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