Louisville vs North Carolina Prediction, Picks & Odds for Tonight’s College Basketball Game

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You’d expect both teams to be at the top of their game when Louisville heads to North Carolina in a pivotal ACC matchup.

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For the Cardinals, being at the top of their game usually means sharpshooter Isaac McKneely is firing on all cylinders. With a very favorable matchup, I expect that to be the case this evening.

My North Carolina vs. Louisville predictions and college basketball picks tell you why I expect the senior to make it rain on Monday, February 23.

Louisville vs North Carolina prediction

Louisville vs North Carolina best bet: Isaac McKneely Over 2.5 3-pointers (+140)

Isaac McKneely is the Louisville Cardinals’ perimeter assassin, and the North Carolina Tar Heels’ defense is built to let him cook.

He’s cashed multiple threes in six straight games while shooting 38% from deep. North Carolina allows just over a point per possession on attack-and-kick actions, ranking in the Bottom 20% of the country defending them.

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At +140, this is a plus-money gift. McKneely posts a staggering 1.33 points per possession as a perimeter sniper on those exact sets. That’s elite efficiency on high volume.

Three triples could very well be the floor.

Louisville vs North Carolina same-game parlay

Louisville has never won two straight games against North Carolina in school history, but there’s reason to suggest that changes. The aforementioned 3-point defensive issue is the driving force, as there are few teams you’d want to face more than Louisville when having this problem.

The other part is the massive, continued absence of Caleb Wilson. Not having a lottery pick impacts… well, everything.

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Louisville’s defense has been a sieve this year in transition and has struggled to defend mobile bigs in the halfcourt. The Tar Heels have that. The story from this game will be the Cardinals simply outscoring UNC in an ACC slugfest.

Louisville vs North Carolina SGP

Isaac…

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Publish date : 2026-02-23 16:09:00

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