March Madness best bets, odds, picks, lines: Respected bettors give their men’s Sweet 16 best bets

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It was a first two rounds full of chalk in the 2025 NCAA tournament, as favorites won 36 of the 48 games (but only went 26-22 against the spread). It was also and a good few days for most sportsbooks, as there were enough upsets to break up money-line parlays on favorites, but unders also went 27-20-1. And we know the public isn’t going to be betting on a ton of unders in March Madness.

Although those lack of upsets may have made the first round less exciting, the Round of 32 featured some fantastic games and the Sweet 16 has some potential barnburners as well.

[A Duke national title could net a bettor over $168K on a $5 championship winners parlay]

Just like I did before the tournament, I’ve asked several sharp handicappers to share a best bet or two they like for the Sweet 16. And remember that just because you’re watching a game, it doesn’t mean you need a wager on it — especially before the game begins. There have been plenty of live betting opportunities (see: Michigan State down most of the first half before winning and covering the original 7.5-point spread against New Mexico) to arise in March Madness if you’re patient and stay disciplined.

Here are four Sweet 16 games that some respected bettors have already wagered on:

All odds courtesy of BetMGM

Thursday

7:09 p.m. ET (CBS)

Mike Randle, FTN Network: Alabama is overly reliant on the three-point shot, and has been making them at a much worse rate than last season. The Crimson Tide shoot 45.6% of their shots from beyond the arc, but are making just 35% from deep. First-year head coach Kevin Young has BYU running an NBA-style offense that ranks top-10 overall in adjusted-offensive efficiency per KenPom. The Cougars rank 35th overall in average height, and will be a worthy adversary for Alabama. BYU has earned impressive road wins over Arizona and Iowa State, and I think Young’s elite offensive sets earn another upset on Thursday.

Bet: BYU +5.5

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Author : Ben Fawkes

Publish date : 2025-03-26 15:39:00

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